The Healthy Kids, Healthy Communities national program supported 49 partnerships to increase access to healthy foods and opportunities for physical activity through policy, systems and environmental change strategies in communities at greatest risk for childhood obesity based on race, ethnicity, income and geographic location. This report provides an overview of the four-year program and includes common themes, key findings and brief vignettes, along with implications for the field. It also provides insights on what is achievable through collaboration among community-based organizations, residents, decision makers and other partners.